傳統(tǒng)動物心電圖測量分析采用體表無創(chuàng)方式，雖操作簡單，但是存在測量位置影響大、測量精度不高等局限性，而心外膜表面電極測量心電圖操作極為復(fù)雜且創(chuàng)傷性大，實(shí)驗(yàn)中較少采用。為解決這一難題，Scisence 提供微創(chuàng)的多電極電生理導(dǎo)管，獨(dú)特設(shè)計使研究者能夠?qū)ι镫娫谡麄€心臟的擴(kuò)散過程進(jìn)行更為深入的測量和分析。

電生理導(dǎo)管系統(tǒng)由八電極電生理導(dǎo)管、電極分配盒及第三方生物電放大器及刺激器組成。

工作原理：八電極電生理導(dǎo)管上的每對電極均受控于電極分配盒，電極分配盒通過 2mm 針式連接線與第三方生物電放大器或刺激器相連，通過生理記錄儀采集對應(yīng)的電極對引導(dǎo)的電信號數(shù)據(jù)。八電極電生理導(dǎo)管可用于心臟起搏，電信號記錄，進(jìn)而用于心臟電生理的各方面研究。

電生理導(dǎo)管系統(tǒng)特點(diǎn)

1. 微創(chuàng)八電極電生理導(dǎo)管，可監(jiān)測心內(nèi)各個部位的心電信號

2. 可同時引導(dǎo)心內(nèi) 4 個不同部位的心電信號，可觀察心電信號的擴(kuò)散過程

3. 同一根導(dǎo)管可同時用于采集信號和給予刺激

4. 小鼠 1.1F，電極間距 0.5mm；大鼠 1.9F，電極間距 1.0mm；導(dǎo)管電極間距可定制

5. 聚酰胺材料制作，生物相容性好，兼顧靈活性和剛性，光滑而便于插入

6. 電極分配盒控制每對電極，電極之間互不影響

7. 兼容多種第三方生物電放大器、刺激器、數(shù)據(jù)采集器，如美國 iWorx 的 iWire-BIOx、IX-RA-834 等

8. 動物實(shí)驗(yàn)用，不能用于人體

LabScribe 心電分析模塊

1. 測量心電圖 R-R、PR、QT、TP、QR、QTc 間隔，QRS、T、P 波寬，P、Q、R、S、T 波幅以及 ST段抬高等數(shù)據(jù)；

2. 具有具體的分析模板，可準(zhǔn)確描繪各波起點(diǎn)、波寬、波幅等；

3. 客戶可定制專門的 ECG 模板，以滿足自身特殊實(shí)驗(yàn)的需要；

4. 可從 R-R 間期、心率、噪音和活動性等方面來劃定異常值，從而使分析更準(zhǔn)確。

5. 可輕松提取源數(shù)據(jù)或平均數(shù)據(jù)作為圖片或文本導(dǎo)出；

6. 可選 ASCII 文本導(dǎo)入模塊將其他第三方設(shè)備采集的 ECG 數(shù)據(jù)導(dǎo)入本軟件進(jìn)行分析；

LabScribe 進(jìn)行心電分析

相關(guān)文獻(xiàn)：

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Guasch E, et. al. “Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model.” J Am Coll Cardiol. 2013 Jul 2;62(1):68-77

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Mathur N, et al. “Sudden infant death syndrome in mice with an inherited mutation in RyR2.” Circ Arrhythm Electrophysiol. 2009 Dec; 2: 677-685